Nils Brose is the head of the Department of Molecular Neurobiology at the Max-Planck-Institute of Experimental Medicine in Göttingen, Germany. He is an expert in the biochemistry, cell biology, and genetics of synaptic transmission, and he has co-pioneered the functional analysis of genes involved in monogenic heritable autism. He has made many important contributions to the field of molecular and cellular neuroscience.
The Max-Planck-Institute of Experimental Medicine comprises three departments and ten research groups, all of which are devoted to neuroscience research. Work in the Department of Molecular Neurobiology is concerned with the analysis of molecular mechanisms of synapse formation and synaptic transmission in the brain, combining mouse genetic approaches with morphological, biochemical, and electrophysiological analyses.
The institute includes a modern transgenic mouse service facility, a state-of-the art proteomics facility with high throughput MALDI-TOF/TOF and high resolution LC-ESI-MS instruments, two-photon and conventional confocal microscopes, and a modern electron microscopy unit, as well as animal behaviour laboratories.
Apart from ongoing research projects, the Department of Molecular Neurobiology will - as a service to the EUROSPIN consortium - (i) provide multiple deletion mutant mouse lines lacking SNARE regulators for electrophysiological and optophysiological analyses, (ii) provide mutant mice expressing fluorescently labeled proteins in defined subcellular compartments (e.g. active zones, synaptic vesicles) as tools for in vivo imaging of synaptogenesis, synaptic function, and synaptic plasticity, and (iii) provide proteomic and DNA sequencing services, as well as support in mouse transgenesis.