Dr. Michael Häusser is working in the field of understanding synaptic integration and dendritic function. He has made important advances in revealing how the integrative properties of single neurons, and in particular of their dendrites, contribute to regulating information flow and memory storage in neural networks; and his group has also been instrumental in developing new approaches for recording from single neurons and small networks of neurons in vitro and in vivo using a combination of optical and electrophysiological approaches.
UCL, with 400 principal investigators, has large and productive groupings of neuroscientists. It represents a rich and fertile environment in which to carry out the proposed work. The Häusser group is housed in the Wolfson Institute for Biomedical Research, an interdisciplinary centre, which offers cutting-edge facilities for biomedical research.
Main Tasks in this Project: The main task of this project partner is the detailed in vivo and in vitro functional analysis of genetic mouse models. This will be carried out using a combination of two-photon imaging and electrophysiology, with which the group has extensive experience. In particular, the ability to make targeted recordings from cerebrellar neurons in vivo, and the ability to manipulate gene expression on the single-cell level (Kitamura et al., Nat Methods 5, 61, 2008) will be particularly relevant. This experimental work will also be complemented by computational modelling of single neurons and neural circuits.