Discovery of neuritogenic compound classes inspired by natural products.

2013/06/03

Dakas PY, Parga JA, Höing S, Schöler HR, Sterneckert J, Kumar K, Waldmann H.

Angew Chem Int Ed Engl. 2013 Sep 2;52(36):9576-81. doi: 10.1002/anie.201302045. Epub 2013 Jun 3.


Neuroactive! An enantioselective, catalytic synthesis strategy provides rapid access to natural-product-inspired classes of neuritogenic compounds. The goal is to find interesting chemical probes to shed light on neurodevelopmental processes and foster a better understanding of the complex biology and physiology of neuronal development and related neurodegenerative disorders.


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