Unraveling mechanisms of homeostatic synaptic plasticity

2010/08/06

Pozo K, Goda Y.

Neuron. 2010 May 13;66(3):337-51 OpenAccess Publication


Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset excessive excitation or inhibition by adjusting their synaptic strengths. Recent findings reveal a complex web of signaling processes involved in this compensatory form of synaptic strength regulation, and in contrast to the popular view of homeostatic plasticity as a slow, global phenomenon, neurons may also rapidly tune the efficacy of individual synapses on demand. Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity.

tl_files/eurospin/images/200px-Open_Access_PLoS.svg.png


PubMed-Abstract site

Free Download

read more about open access in EU-funded projects

Go back