Herbert Waldmann is the head of the Department of Chemical Biology, MPI, Dortmund, professor, principal investigator, expert in organic chemistry, biochemistry, signal transduction and chemical biology. He has made numerous contributions to the fields of chemistry and chemical biology, for instance, solid phase compound collection synthesis and biological evaluation, syntheses of signal transduction modulators, synthesis and biological evaluation of lipidated peptides and proteins as well as protein microarray technology etc.
The Max Planck Institute of Molecular Physiology (MPI, Dortmund) houses Departments of structural biology, systemic cell biology, physical biochemistry and chemical biology. It is known as one of key centres in chemical biology research worldwide. Research at MPI, Dortmund focuses on molecular pathways underlying the highly complex biological processes. Research in the Department of Chemical Biology (H. Waldmann) is focused on the interface between organic chemistry and biology. The group is very active in using smart molecules to study a range of signal transduction pathways, e.g. Ras and Wnt signalling pathways; investigating the role of lipidated proteins in signalling and vesicular transport and in defining the bioactive regions of the chemical and proteomic space leading to biology oriented synthesis of interesting classes of small molecules for various disease targets. The Chemical Genomics Center (CGC) and MPG Lead Discovery Center work in close collaborations with the departments of the MPI, Dortmund and provide excellent opportunities to realize the therapeutic applications to the basic research work performed there.
Main Tasks in this Project: The main task is to create small molecule libraries based on the molecular architectures of natural products and the hits from the high throughput screenings (HTS). The compound collections shall be screened to identify molecules which can interfere with the protein-protein interactions of relevance to synapse and synaptopathies. The smart libraries shall be further employed for biochemical and cellular screenings to provide SAR leading to linker synthesis and target identification studies.