Erich Wanker is head of the group and an expert in biochemistry, cell biology, proteomics and genetics of neurodegenerative disorders. He has pioneered the systematic identification of human protein-protein interactions with automated Y2H screenings.
The Max Delbrück Center for Molecular Medicine (MDC) in Berlin-Buch is one of 15 research centers in the Helmholtz Association, Germany’s largest publicly funded research organization. The MDC Neuroscience Research Program focuses on molecular and cellular biology of the nervous system in health and disease. The research group “Proteomics and Molecular Mechanisms of Neurodegenerative Diseases” of Prof. E. Wanker investigates the proteome and pathomechanisms of late onset neurodegenerative disorders such as Huntington’s, Parkinson’s and Alzheimer’s disease.
Main Task in this Project: The main task of this partner project is the systematic identification and analysis of protein-protein interactions critical for synapse function. Using high-throughput (HTP) screening and bioinformatics tools, a comprehensive interaction map of synaptic proteins will be created to identify and characterize functional modules and potential drug targets. The synapse interactome data will be validated with independent methods such as co-immunoprecipitation in cellular and in vivo model systems.